Pharmacological Activation of Rev-erb<i>α</i> Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1<i>α</i> Signaling Pathway

<div>Effects of SR9009 and PGC-1<i>α</i> siRNA on cell apoptosis, ROS generation, cellular ATP content, MDA content, and SOD and GSH-Px activities in doxorubicin-treated H9c2 cells. (a) Representative images of cell apoptosis analyzed by flow cytometry. The horizontal axis represents Annexin V-FITC, and the vertical axis represents propidium iodide. (b) Representative western blot results of Bcl2 and cleaved caspase 3 are shown; GAPDH was used as an internal control. (c) Representative images of ROS generation analyzed by flow cytometry. The horizontal axis represents fluorescent intensity, and the vertical axis represents cell count. (d) Cellular ATP content, MDA content, SOD activity, and GSH-Px activity. 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Cardiovascular Therapeutics

fig2

Figure 2

Figure 2: Pharmacological Activation of Rev-erb<i>α</i> Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1<i>α</i> Signaling Pathway 

Cardiovascular Therapeutics

Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway

Figure 2