Pharmacological Activation of Rev-erb<i>α</i> Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1<i>α</i> Signaling Pathway

<div>Effects of SR9009 on cardiotoxicity in doxorubicin-treated mouse heart. (a) Representative HE staining images of left ventricle. Scale bar: 100 <i>μ</i>m. (b) Representative ultrastructural morphology images of mitochondria of left ventricle. Scale bar: 4 <i>μ</i>m. Black arrows: swollen mitochondria with cristae disorientation and breakage; white arrowheads: normal mitochondria. (c) Representative ROS generation of heart tissue analyzed by flow cytometry. The horizontal axis represents fluorescent intensity, and the vertical axis represents cell count. (d) MDA content, SOD activity, and GSH-Px activity of heart tissue. 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Cardiovascular Therapeutics

fig4

Figure 4

Figure 4: Pharmacological Activation of Rev-erb<i>α</i> Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1<i>α</i> Signaling Pathway 

Cardiovascular Therapeutics

Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway

Figure 4