Research Article
Social App to Improve Warfarin Therapy in Post-MHVR Chinese Patients: A Randomized Controlled Trial
Table 2
Primary and secondary outcomes.
| | End points | Routine care group | Social app group | Adjusted HR (95% CI) | value |
| | Primary endpoints | | | | | | Major bleedings (, %) | 21 (2.92) | 9 (1.25) | 2.30 (1.04-5.69) | 0.0397 | | Thrombotic events (, %) | 15 (2.09) | 12 (1.67) | 1.17 (0.54-2.55) | 0.685 | | Secondary endpoints | | | Difference or odds ratio (95% CI) | | | Mean TTR (%) | | | -18.8 (-20.8 to -16.8) | <0.001 | | (%) | 8.15 (29/356) | 58.0 (212/362) | -15.9 (-24.6 to -10.3) | <0.001 | | INR variation | | | 0.14 (-0.11-0.18) | <0.001 | | Extremely high INR | | | | | | (, %, total) | 245 (3.42, 7169) | 82 (0.87, 9425) | | <0.001 | | (, %, total) | 27 (0.38, 7169) | 1 (0.00, 9425) | | <0.001 | | Event details | | | | | | Cerebral haemorrhage () | 3 | 2 | | | | Gastrointestinal bleeding () | 14 | 5 | | | | Pulmonary haemorrhage () | 1 | 0 | | | | Other bleeding () | 3 | 2 | | | | Valve thrombosis () | 2 | 1 | | | | Stroke () | 8 | 6 | | | | Atrial thrombosis () | 1 | 0 | | | | Myocardial infarction () | 2 | 3 | | | | Peripheral embolism () | 2 | 1 | | | | Pulmonary embolism () | 0 | 1 | | |
|
|
TTR: time in therapeutic range; INR: international normalized ratio; HR: hazard ratio; 95% CI: 95% confidential interval.
|
