Drug-Coated Balloon-Only Strategy for De Novo Coronary Artery Disease: A Meta-analysis of Randomized Clinical Trials

Table 2

Pooled estimates of effects (95% confidence intervals) for DCB vs. control treatment for secondary endpoints.

Secondary endpoints	DCB vs. DES					DCB vs. uncoated devices
		Pooled estimate (95% CI)	Prediction interval				Pooled estimate (95% CI)	Prediction interval
Clinical endpoints
TLR	8	1.15 (0.56, 2.34)	(0.17, 7.76)	0.705	51.1%	8	0.42 (0.23, 0.76)	(0.23, 0.76)	0.004	0.0%
Death/cardiac death	10	0.95 (0.61, 1.48)	(0.61, 1.48)	0.825	0.0%	8	0.39 (0.16, 0.94)	(0.16, 0.94)	0.036	0.0%
MI	8	0.80 (0.49, 1.32)	(0.49, 1.32)	0.387	0.0%	8	0.31 (0.13, 0.74)	(0.13, 0.74)	0.008	0.0%
Angiographic endpoints
Binary restenosis	6	1.06 (0.74, 1.51)	(0.74, 1.51)	0.748	0.0%	5	0.31 (0.22, 0.45)	(0.22, 0.45)	<0.001	0.0%
MLD	10	-0.48 (-0.67, -0.29)	(-1.05, 0.10)	<0.001	59.7%	6	0.54 (0.31, 0.76)	(-0.09, 1.17)	<0.001	52.7%
DS%	7	0.24 (0.09, 0.40)	(-0.06, 0.55)	0.001	19.1%	6	-0.67 (-0.89, -0.44)	(-1.28, -0.05)	<0.001	51.1%

: number of eligible studies included. Abbreviations: CI: confidence interval; DCB: drug-coated balloon; DES: drug-eluting stents; DS%: percent diameter stenosis; MI: myocardial infarction; MLD: minimum lumen diameter; TLR: target lesion revascularization.