KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing

Figure 2

TRAM-34 attenuates inflammation in atrial tissue during rapid pacing. (a) Representative images of inflammation and fibrosis, as reflected by the H&E staining and Masson staining. Black arrows indicate the infiltration of inflammatory cells. (b, c) Representative images of CD68, as reflected by immunofluorescence analysis. White arrows indicate CD68-positive macrophages. (d–g) RT-PCR analysis of Arg-1, iNOS, IL-1β, and IL-6 expression normalized to GAPDH in atrial tissue during rapid pacing. The data are presented as the of three to six biological replicates. , , and indicate , 0.01, and 0.001, respectively.

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