KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing

Figure 3

TRAM-34 attenuates the secretion of exosomes in atrial tissue during rapid pacing. (a) Representative images of KCa3.1 and Rab27a, as reflected by immunohistochemistry. (b, c) Representative images of CD81, as reflected by immunofluorescence analysis. (d) Representative gel bands showing the effects of TRAM-34 administration on atrial tissue during rapid pacing. (e–i) Levels of KCa3.1, p-AKT/AKT, Rab27a, TSG101, and CD81. The data are presented as the of three to six biological replicates. , , and indicate , 0.01, and 0.001, respectively.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)