Effect of TRIB1 Variant on Lipid Profile and Coronary Artery Disease: A Systematic Review and Meta-Analysis

Table 1

Meta-analysis of TRIB1 rs17321515 variant with lipid profile.

Groups or subgroups	Comparisons (subjects)	PH	SMD (95% CI)	PSMD
TG
All	13 (18 466)	<0.001	0.11 (0.07-0.14)	<0.001
Studies in HWE	11 (17 672)	<0.001	0.20 (0.08-0.32)	<0.01
Asian	12 (13 495)	<0.001	0.18 (0.03-0.32)	0.02
Male	3 (1 158)	0.25	0.08 (-0.08-0.24)	0.32
Female	3 (1 139)	0.48	0.00 (-0.13-0.13)	0.94
General population	10 (15 229)	<0.001	0.17 (0.05-0.29)	0.01
TC
All	12 (8 828)	0.64	0.08 (0.02-0.13)	0.01
Studies in HWE	10 (8 034)	0.45	0.08 (0.02-0.14)	0.01
Asian	12 (8 828)	0.63	0.08 (0.02-0.13)	0.01
Male	3 (1 158)	0.50	-0.01 (-0.14-0.12)	0.87
Female	3 (1 139)	0.99	0.04 (-0.09-0.18)	0.50
General population	9 (5 591)	0.76	0.08 (0.02-0.14)	0.01
LDL-C
All	14 (21 399)	0.86	0.07 (0.04-0.11)	<0.001
Studies in HWE	12 (20 605)	0.77	0.08 (0.04-0.11)	<0.001
Asian	13 (16 428)	0.83	0.07 (0.03-0.11)	<0.001
Male	3 (1 158)	0.09	0.07(-0.06-0.20)	0.29
Female	3 (1 139)	0.89	0.04 (-0.09-0.17)	0.53
General population	11 (18 162)	0.78	0.07 (0.04-0.11)	<0.001
HDL-C
All	14 (21 399)	0.14	-0.02 (-0.05-0.01)	0.25
Studies in HWE	12 (20 605)	0.12	-0.02 (-0.05-0.01)	0.18
Asian	13 (16 428)	0.33	0.00 (-0.04-0.04)	0.94
Male	3 (1 158)	0.01	-0.02 (-0.15-0.11)	0.78
Female	3 (1 139)	0.59	0.07 (-0.06-0.21)	0.29
General population	11 (18 162)	0.07	-0.02 (-0.05-0.01)	0.26

SMD: standardized mean difference; 95% CI: 95% confidence interval; P_H: P_{Heterogeneity;} HWE: Hardy-Weinberg equilibrium; TG: triglycerides; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol.