The Effect of Clinically Indicated Liraglutide on Pericoronary Adipose Tissue in Type 2 Diabetic Patients

Table 3

Multiple linear regression: unadjusted and adjusted differences in PCAT attenuation between Lira+ and Lira- for each coronary artery.

	CX		LAD		RCA
	coefficient (95% CI)	value	coefficient (95% CI)	value	coefficient (95% CI)	value
Unadjusted	0.185 (-1.86; 2.23)	0.859	-1.452 (-3.58; 0.67)	0.179	-0.110 (-2.46; 2.24)	0.926
Adjusted for age, sex, and BMI	-0.063 (-2.04; 1.92)	0.950	-1.645 (-3.75; 0.45)	0.124	0.15 (-2.18; 2.48)	0.898
Adjusted for age, sex, BMI, and T2DM duration	-0.242 (-2.29; 1.81)	0.816	-2.417 (-4.58; -0.25)	0.029	-0.149 (-2.61; 2.31)	0.905
Adjusted age, sex, BMI, lipid-lowering medication, antihypertensive medication, and active smoking	-0.060 (-2.07; 1.95)	0.953	-1.907 (-4.02; 0.21)	0.077	0.499 (-1.85; 2.85)	0.676
Adjusted for age, sex, BMI, lipid-lowering medication, antihypertensive medication, active smoking, and T2DM duration	-0.291 (-2.36; 1.78)	0.782	-2.607 (-4.78; -0.44)	0.019	-0.078 (-2.53; 2.38)	0.950

Abbreviations: CX: left circumflex artery; LAD: left anterior descending artery; RCA: right coronary artery; Lira+: in clinically indicated liraglutide treatment; Lira-: no liraglutide treatment; BMI: body mass index; T2DM: type 2 diabetes mellitus; CI: confidence interval; HU: Hounsfield unit. Coronary artery segments with insufficient image quality were excluded from the analysis. Consequently, analysis for CX included 182 (50 Lira+/132 Lira-), LAD included 188 (53 Lira+/135 Lira-), and RCA included 184 (52 Lira+/132 Lira-) segments. The coefficients and the 95% CI are for liraglutide in the multiple linear regression models.