Effect of Statins on Major Adverse Cardiovascular Events in Patients with Coronary Artery Spasm: A Meta-Analysis of the Asia Region
Table 2
Clinical outcomes and main characteristics of patients with coronary artery spasms treated with statins or without statins.
Study
Year
Country
Total ()
Statins ()
Age (y)
Male (, %)
MACE definition
MACE ()
Follow-up
Kensuke Io et al.
2007
Japan
1047
129
(all)
NR
Death from MI, cerebral infarction, or HF and nonfatal MI
3 vs. 31
3.7 y
Sunao Kodama et al.
2009
Japan
292
71
(all)
NR
Fatal cardiovascular disorder, acute MI, cerebrovascular disorder, HF, aortic aneurysm, renal failure, and obstructive atherosclerosis, undergoing cardiac surgery
3 vs. 13
4.3 y
Munenori Kosugi et al.
2011
Japan
231
87
NR
NR
Sudden cardiac death and readmission for ACS
7 vs. 22
5.9 y
Akihiro Nakagomi et al.
2013
Japan
265
98
(all)
NR
Sudden cardiac death and readmission for ACS
5 vs. 26
7.4 y
Masanobu Ishii et al.
2016
Japan
256
128
vs.
55 (43.0) vs. 57 (44.5)
Cardiac death, hospitalization for acute MI, and unstable angina
0 vs. 9
4.6 y
Min Seok Oh et al.
2016
South Korea
562
281
vs.
238 (84.7) vs. 241 (85.8)
Cardiac death, MI, any revascularization
9 vs. 12
4.6 y
Zhe Hao Piao et al.
2016
South Korea
501
292
vs.
201 (69.3) vs. 145 (69.4)
All-cause death, nonfatal MI, and TVR
5 vs. 12
1.0 y
So Jin Park et al.
2019
South Korea
4099
2304
vs.
1706 (74.1) vs. 1244 (69.3)
Cardiac arrest and acute MI after discharge
120 vs. 97
3.9 y
Won-Woo Seo et al.
2020
South Korea
1658
744
vs.
461 (62.0) vs. 544 (59.5)
Cardiac death, ACS, and new-onset life-threatening arrhythmia
32 vs. 28
1.9 y
Hiroyoshi Mori et al.
2022
Japan
422
211
vs.
157 (74.4) vs. 157 (74.4)
Cardiac death, nonfatal MI, hospitalization due to unstable angina pectoris, HF, and appropriate implantable cardioverter defibrillator shock
10 vs. 13
2.6 y
Statin group vs. no-statin group; age is expressed in average values (SD). MI: myocardial infarction; HF: heart failure; ACS: acute coronary syndrome; TVR: target vessel revascularization.
