miR-135a Regulates Atrial Fibrillation by Targeting Smad3

Figure 2

miR-135a was downregulated in HES and hypoxia-treated AFs. mRNA (a) and protein (b) levels of collagen I and α-SMA in AFs treated with HES for 0 h, 6 h, and 12 h. (c) Relative expression of miR-135a in HES-stimulated AFs and cellular supernatants; mRNA (d) and protein (e) levels of collagen I and α-SMA in AFs after hypoxia 0 h, 6 h, 12 h, and 24 h. (f) Relative expression of miR-135a in hypoxia-stimulated AFs and cellular supernatants. The levels of proteins were relative to GAPDH expression. (, ).

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