Research Article
DUSP22 Ameliorates Endothelial-to-Mesenchymal Transition in HUVECs through Smad2/3 and MAPK Signaling Pathways
Figure 4
DUSP22 affects the smad2/3 signaling pathway. sh-DUSP22 activates the smad2/3 signaling pathway. The (a) protein representative blots and (b) quantitative results and the (c) mRNA expression changes of the downstream molecules of smad2/3 signaling pathway. vs. sh-NC. # vs. sh-NC+TGF-β. OEDUSP22 inactivates the smad2/3 signaling pathway. The (d) protein representative blots and (e) quantitative results and the (f) mRNA expression changes of the downstream molecules of smad2/3 signaling pathway. vs. OENC. ## vs. OENC+TGF-β. After adding with smad2/3 inhibitor ITD-1, the (g) mRNA expression changes and the (h) protein representative blots and (i) quantitative results of the phenotypic molecule of EndMT. 1 vs. sh-NC. 2 vs. sh-NC+TGF-β. 3 vs. sh-DUSP22. 4 vs. sh-DUSP22+TGF-β.
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