A Low-Noise, Modular, and Versatile Analog Front-End Intended for Processing In Vitro Neuronal Signals Detected by Microelectrode Arrays

Figure 9

(a) Scatter plot representing SNR values (dB) of electrodes recorded with both the benchmark system (-axis) and the custom boards (-axis). electrodes extracted by 4 MEA chips. SNR are median values over the spikes detected at each electrode. Dashed line, bisector of the graph, indicating the localization of points in the ideal case of identical SNR values. (b) Histograms of SNR values of MEA signals collected from hippocampal cultures on MEAs () recorded with the custom board (light gray) and with the commercial system (dark gray). Histograms are reported as median SNR over the spiking channels, with bars spanning from the 25th to the 75th percentile. For all the pairs, SNR values were not statistically different (, Wilcoxon matched pair test).

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