Simulation of Code Spectrum and Code Flow of Cultured Neuronal Networks

Figure 9

Code spectra. The blue curve shows the average of trials of an experimental number of codes detected from 63 electrodes in spike trains during 200 ms after stimulation expressed with 2000 time bins of 0.1 ms. The bit width of the code is 0.6–2.0 ms (6–20 bins). Codes are detected with 1% time accuracy, although practically several % because of the 0.1 ms bit width. This curve can be considered as the “signature” of spike trains. The orange curve is the best fit to code spectrum using a simulation spectrum.

(a) Sample A (9 trials). Estimated  ms, , and probability distribution of () is (0.3, 0.1, 0, 0, 0, 0.05, 0, 0.55), with a normalized RMS error of 0.179

(b) Sample B (23 trials). Estimated  ms, , and probability distribution of () is (0.3, 0.1, 0, 0, 0, 0.05, 0, 0.55), with a normalized RMS error of 0.181

(c) Sample C (26 trials). Estimated  ms, , and probability distribution of () is (0.263, 0.158, 0, 0.053, 0.053, 0.053, 0.421, 0), with a normalized RMS error of 0.180