RNA-Seq-Based Breast Cancer Subtypes Classification Using Machine Learning Approaches

Figure 5

Flowchart for conducting the GOEGCN analysis using weighted DEGs. (a) First of all, the initial enriched GO terms are obtained using GO enrichment analysis. Then a sub symmetric coexpression matrix of “geneID” from each GO term for control or experiment group is constructed, and the interaction network structures of original symmetric coexpression matrix for control or experiment group are regarded as the background. (b) Adopt equations (2) and (3) to recalculate the values for control and experiment groups, respectively. (c) Collect and reorder the results of enriched GO terms which are recalculated and form the final enriched GO terms list for control and experiment groups, respectively.