Simulations of Myenteric Neuron Dynamics in Response to Mechanical Stretch

Figure 2

Model generalization: to test the optimized model, we compared the model responses (solid lines) to a new input current and stretch ratio with the corresponding experimentally recorded membrane potentials of three different neurons (dashed lines). These experimental traces have not been used during the optimization. (a) Comparison between the experimental recordings (dashed line) of the porcine sAHP neuron, to 60 pA, with 120 ms injection of rectangular electrical current pulses and the model prediction (solid lines) to the same input by using the parameters listed in Table 1: sAHP neuron. (b) Comparison between the experimental recordings (dashed line) of the porcine mAHP neuron, to 50 pA, with 200 ms injection of rectangular electrical current pulses and the model prediction (solid lines) to the same input by using the parameters listed in Table 1: mAHP neuron. (c) Comparison between the experimental recordings (dashed line) from a single Dogiel type II neuron in the tissue strip under 40% longitudinal stretch and 100PA with 500 ms injection of the current pulse and the model response (solid lines) to the same input by using the parameters listed in Table 1: neuron under stretch, where G_m = 0.0838 S/cm² was used for the model generalization. The experimental recordings of sAHP and mAHP were reproduced from Figure 1C (sAHP) and Figure 3B (mAHP) in the study by Cornelissen et al. [21]. The mechanical stretch neurons were from Figure 5Bb in the study by Kunze et al. [2].

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