Integration of Genetic and Immune Infiltration Insights into Data Mining of Multiple Sclerosis Pathogenesis

Table 2

The first 10 core genes obtained from Cytohubba plug-in and genes of 5 gene sets from the MCODE plug-in.

Gene sets	Gene lists
Top 10 hub genes	HLA-DRA, HLA-DRB1, HLA-DRB5, HLA-DQB2, HLA-DPA1, HLA-DQB1, HLA-E, HLA-C, GBP2, CD44
Cluster 1	ACTR1B, HLA-DRB5, HLA-DQB2, HLA-DPA1, HLA-DMB, B2M, HLA-DRA, HLA-DMA, HLA-DRB1, HLA-DQB1, IRF8, KLC2, DYNLL2, DYNC1I1, GBP2, GBP1, DNAJC3, HLA-C, HLA-E, IFI30, CD44, IRF3, TMEM132A, LGALS1, PRKCSH, FSTL1, LTBP1, IGFBP7, CHGB, ADCY1, CALU, DRD4, HSP90B1, GNB4, HTR5A, CXCL16, CP, GNG3, CCR1, SPP1, C5AR1, ANXA1, GNG12, ADORA1, GNAI3, APOE, TIMP1
Cluster 2	WWP1, FBXO30, KLHL22, FBXO44, FBXL4, UBE2S, DTX3L, MGRN1, RNF126
Cluster 3	CD2BP2, PAPOLA, SYMPK, FUS, U2AF1L4, POLR2G, ELAVL2, PLRG1, PRPF31
Cluster 4	OLR1, CD300A, TMEM63A, ITGAV, COL8A1, ATP6V0C, P4HA1, PLOD2, COL1A2, COL9A3, COL8A2, P4HA2, COL4A2, CYBA, COL4A1, CD33, SERPINH1, CD53
Cluster 5	GPR65, GNRH1, P2RY2, CCKBR, TAC3, CCK, PIK3CA