[Retracted] NOD1 and NOD2 Are Potential Therapeutic Targets for Cancer Immunotherapy

Figure 4

Potential mechanism of NOD1 and NOD2 in cancer. NOD1 exerts antitumor efficacy via apoptosis, whereas uncontrolled apoptosis-mediated by NOD1 would induce immunosuppression regulated by NOD1 and hence promotes tumor proliferation. Furthermore, the antitumor function of NOD2 is dependent on identifying and binding bacteria and their derivatives, when this connection is inadequate, NOD2 contributes to chronic inflammation and promotes cancer.