RGD-Hydrogel Improves the Therapeutic Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Phosgene-Induced Acute Lung Injury in Rats

Figure 3

Effects of the hydrogel-encapsulated MSCs on P-ALI rat model. (a) The lung wet-to-dry ratio in the groups after 6, 24, and 48 h of interference. (b) Total protein concentration in BALF samples of the groups at different time points. (c) The levels of receptor expression for RAGE in BALF samples of the groups after 6, 24, and 48 h of treatment. (d) The levels of TNF-α, IL-1β and IL-6 in BALF samples of different groups after 6, 24, and 48 h of treatment using ELISA kits. (e) The levels of TNF-α, IL-1β and IL-6 in serum samples of different groups after 6, 24, and 48 h of treatment using ELISA kits. (f) Histological changes in lung tissues of the groups using HE staining (Bar = 200 μm). (g) The protein expression of SPC and MMP9 in lung tissues of different groups by western blot. :  < 0.05, :  < 0.01.

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