Analyzing Prognostic Hub Genes in the Microenvironment of Cutaneous Melanoma by Computer Integrated Bioinformatics

Table 1

The type and frequency of 19 hub gene alterations in CM (cBioPortal).

Categories	Gene symbol	Mutation	Amplification	Homozygous deletion	Up regulation	Multiple alterations	Total alteration
Cell surface	CD3E	0.27	0	2.97	5.41	0	8.65
	CD69	1.08	1.08	0.27	2.97	0	5.4
	CD274	0.27	1.08	1.35	2.16	0.27	5.13
	KLRD1	1.62	1.08	0.27	5.14	0	8.11
	PDCD1	1.08	0	2.16	5.14	0	8.38
	LAG3	1.36	0.81	0.27	5.15	0	7.59
	IL7R	7.84	3.24	0	3.24	0.54	14.86
	HLA-DRB5	0.27	0	0	4.32	0	4.59
Toll-like receptors	LILRB4	9.19	0.27	0	5.95	0.54	15.95
	TNFRSF18	1.08	1.08	1.35	4.86	0	8.37
	TRAT1	3.78	0.27	0	6.49	0	10.54
	PDCD1LG2	0.54	0.81	1.35	3.78	0.54	7.02
Complements	C1QB	1.89	1.62	0.81	6.49	0	10.81
	GZMK	1.08	0.54	0	4.59	0.27	6.48
	C1QC	2.16	1.35	0.81	6.49	0.54	11.35
Integral component of membrane	CXCL13	0.54	0.27	0	3.24	0	4.05
	FLT3	8.65	0.27	0	4.86	0	13.78
Other	IDO1	2.97	0.54	0.54	3.51	0.81	8.37
	IRF1	0.27	0	0.54	4.86	0.27	5.94

Genes in bold have not been previously reported to be associated with prognosis of CM patients.