Computational Intelligence and Neuroscience

Research Article

The Efficacy and Safety of Mizoribine versus Mycophenolate Mofetil for the Treatment of Renal Transplantation: A Systematic Review and Meta-Analysis

Table 1

Trial design and baseline characteristics of the 12 trials included in the meta-analysis.
StudyCountryLanguageStudy designNo. of patientsGender (M/F)AgeDosagesFollow-upDuration
MZRMMFMZRMMFMZRMMFMZRMMF
Ming 2003ChinaChineseRCT2020----100 mg/d1.5 g/d6 months2001
Yan 2008ChinaChineseRCT100100----50–100 mg/d1 ∼ 1.5 g/d12 months2002
Han 2010ChinaChineseRCT353523/1223/1241.6 ± 10.542.1 ± 10.6150–200 mg/d1 ∼ 1.5 g/d12 monthsSeptember 2004 to November 2005
Chen 2012ChinaChineseRCT332821/1218/1040.2 ± 11.538.6 ± 9.9150–200 mg/d1 ∼ 1.5 g/d6 monthsJanuary 2010 to October 2010
Ju 2013KoreaEnglishRCT11010970/4064/4544.6 ± 10.944.2 ± 11.1100–300 mg/d1 ∼ 2 g/d6 monthsJuly 2008 to January 2011
Takahara 2013JapanEnglishRCT16199/715/436.1 ± 7.239.7 ± 11.3350–600 mg/d1 ∼ 2 g/d12 monthsJuly 2005 to June 2007
Yoshimura 2013JapanEnglishRCT403823/1720/1841 ± 1335 ± 146 mg/kg/d25 mg/kg/d24 monthsOctober 2004 to July 2007
Yoshimura 2014JapanEnglishRCT12127/55/750 ± 1050 ± 136 mg/kg/d1 g/d36 monthsOctober 2007 to April 2010
Ishida 2016JapanEnglishRCT414226/1527/1541.7 ± 14.442.3 ± 12.5700 mg/d2 g/d12 monthsOctober 2008 to December 2013
Ushigome 2016JapanEnglishRCT908156/3450/3142.5 ± 13.539.2 ± 13.16 mg/kg/d30 mg/kg/d24 monthsFebruary 2006 to June 2008
Shi 2019ChinaEnglishRCT222020/216/430.4 ± 7.729.4 ± 8.43 mg/kg/d1.5 g/d36 monthsJanuary 2012 to August 2014
Huang 2020ChinaEnglishRCT404021/1918/2227.5 (3–57)28.5 (6–54)3 mg/kg/d15 mg/kg/d50.7 monthsMarch 2014 to March 2017
MZR, mizoribine; MMF, mycophenolate mofetil.