|
| Author, year | Study design | Location | Number assigned/evaluated | Age | Control | PRP preparation | Treatment | Treatment time | Follow-up |
|
| Hofny et al. 2019 [3] | Prospective before-and-after self-control studies | Egypt | 23/23 | 21–50 | before-and-after self-control | (1) Double centrifugation | (1) Used PRP alone | Three sessions (four-week intervals) | 1 month |
| (2) 10 minutes at 1600 rpm | (2) Hemi-face study |
| (3) 10 minutes at 4000 rpm | (3) Intradermal injections on the left side and microneedling before and after PRP application on the right side |
| Sirithanabadeekul et al. 2020 [4] | Randomized, split-face, single-blinded prospective trial | Thailand | 10/10 | 33–58 | Intradermal normal saline injection | (1) Single centrifugation | (1) Used PRP and saline | Four times every two weeks | 1 month |
| (2) Hemi-face study |
| 2.4 minutes at 3200 rpm | (3) Unilateral intradermal injection of PRP and the other side was injected with saline |
| Tuknayat et al. 2020 [17] | Prospective before-and-after self-control studies | India | 64/65 | — | before-and-after self-control | (1) Single centrifugation | (1) Used PRP alone | Three sessions (four-weeks intervals) | 3 months |
| (2) 8 minutes at 3500 rpm | (2) Autologous PRP injections |
| Mumtaz et al. 2021 [1] | Nonrandomised controlled trial | Pakistan | 64/64 | 20–40 | Intradermal tranexamic acid | (1) Double centrifugation | (1) Used PRP and tranexamic acid | Three sessions (four-week intervals) | 6 months |
| (2) Grouping study |
| (2) 10 minutes at 1500 rpm | (3) Experimental group: intradermal injection of PRP |
| (3) 10 minutes at 4000 rpm | Control group: intradermal tranexamic acid |
| Adel et al. 2021 [18] | Randomized prospective split-face study | Egypt | 20/20 | — | Intradermal injection of PRP vs intradermal injection of PRP + IPL | — | (1) Used PRP and IPL | Four sessions (two-week intervals) | 1 month |
| (2) Hemi-face study |
| (3) One side: intradermal injection of PRP |
| The other side: intradermal injection of PRP + IPL |
| Gamea et al. 2020 [19] | Randomized controlled trial | Egypt | 40/40 | 32–58 | Topical 5% tranexamic acid | (1) Double centrifugation | (1)Used PRP and tranexamic acid | Topical tranexamic acid (twice daily for 12 weeks | 1 month |
| (2)Grouping study |
| (2) 3 minutes at 2000 rpm | (3) Experimental: topical tranexamic acid and intradermal injection of PRP | |
| (3) 5 minutes at 5000 rpm | Control group: topical tranexamic acid |
| Tuknayat et al. 2021 [2] | Prospective before-and-after self-control studies | India | 40/40 | — | — | (1) Double centrifugation | (1) Used PRP alone | Three sessions (one-week intervals) | 3 months |
| (2) 10 minutes at 1600 rpm | (2) Intradermal injection of PRP |
| (3) 10 minutes at 4000 rpm | |
| Faiz and Meng 2018 [20] | Prospective before-and-after self-control studies | Pakistan | 20/15 | 21–42 | before-and-after self-control | (1) Double centrifugation | Intradermal injection of PRP | Five sessions (two-week intervals) | 2 weeks |
| (2) 3 minutes at 1500 rpm |
| (3)5 minutes at 4000 rpm |
|
