|
| Study | Group | MASI | mMASI | Degree of improvement N (%) | Patient satisfaction N (%) | Adverse effects N (%) | Other outcomes |
| Before | After | Before | After |
|
| Faiz and Meng 2018 [20] | — | 15.71 ± 6.81 | 4.98 ± 2.13 | | | MASI: | — | Temporary | — |
| Poor (0–25% decrease) 4 (26.7) | Mild erythema: 2(13.3) |
| Fair (26–50% decrease) 9 (60) | |
| Good (51–75% decrease) 2 (13.3) | |
| Excellent (>75% decrease) 0 (0) | |
| Hofny et al. 2019 [3] | A: microneedling with Dermapen
B: microinjections using mesoneedles | 11.86 ± 5.25 | 6.96 ± 4.82 | 5.71 ± 2.56 | 2.90 ± 2.05 | mMASI: | Very satisfied: 9 (39.1) | Swelling, redness and soreness | |
| Excellent (>75–100% decrease): 3 (13) | Satisfied: 9 (39.1) |
| Significant (>50–75% decrease): 8 (34.8) mild (>25–50% decrease): | Slight satisfaction: 3 (13.1) |
| 9 (39.2) | Unsatisfied: 2 (8.7) |
| Slight (0–25% decrease): 3 (13.0) | |
| MASI: | |
| Excellent (>75–100% decrease): 3 (13.1) | |
| Significant (>50–75% decrease): 5 (21,7) mild (>25–50% decrease): 10 (43.5) | |
| Slight (0–25% decrease): 5 (21.7) | |
| Sirithanabadeekul et al. 2020 [4] | A: intradermal PRP injection
B: intradermal saline injection | A: 4.92 ± 0.96
B: 4.98 ± 0.86 | A: 3.5 ± 0.67
B: 4.53 ± 0.96 | — | — | — | From baseline to the end of treatment, the patients’ satisfaction under PRP condition was significantly improved at the time of visit | Bruising | Mean melanin levels; |
| A: |
| Before: |
| 256.73 ± 17.68 |
| After: |
| 238.63 ± 16.4 |
| B: 246.57 ± 22.88 (before) |
| 249.47 ± 21.36 (after) |
| Tuknayat et al. 2020 [17] | — | — | — | | 47.3% reduction | mMASI: | — | Xerosis | |
| Excellent (>75% decrease): 4 (6.25) | Hyperpigmentation |
| Significant (51–75% decrease): 21 (32.8) mild (26–50% decrease): 27 (42.1) | |
| Slight (1–25% decrease): 10 (15.6) | |
| No minimal (0% decrease): 2 (3.1) | |
| Mumtaz et al. 2021 [1] | A: intradermal platelet-rich plasma | A: 29.84 ± 5.14 | A: 8.72 ± 3.40 | — | — | — | — | — | — |
| B: intradermal tranexamic | B: 29.56 ± 4.39 | B:14.97 ± 4.33 |
| Adel et al. 2021 [18] | A: PPL | 16.3 ± 7.7 | 10.9 ± 6.3 | A: 19 ± 6.4 | A: 14.2 ± 5.8
B: 14.6 ± 5.5 | MASI: | No significant difference between both sides | — | — |
| B: PRP + IPL | B: 19.8 ± 5.8 | 33.13% improvement mMASI: |
| | | No significant difference between both sides |
| Gamea et al. 2020 [19] | A: topical5% | — | — | A: 12.1 ± 2.9 | A: 3.6 ± 1.9 | mMASI: | A: | Hyperpigmentation: | |
| B: topical 5% tranexamic acid | | | A: | Highly satisfied: 5 (25) mildly satisfied: | A: 1 (5) |
| | | | Excellent (75–100% decrease): 3 (15) | 10 (50) | B: 2 (10) |
| | | | Significant (50–74% decrease): 4 (20) mild (25–49% decrease): 12 (60) | Partially satisfied: 3 (15) | Erythema: |
| Slight (0–24% decrease): 1 (5) | Not satisfied: 2 (10) | A: 10 (50) |
| B: | B: | B: 0 (0) |
| | | | Excellent (75–100% decrease): 1 (5) | Highly satisfied: 3 (5) mildly satisfied: 2 (10) | Pain: |
| Significant (50–74% decrease): 3 (15) mild (25–49% decrease): 7 (35) | Partially satisfied: 4 (20) | A:12 (60) |
| Slight (0–24% decrease): 9 (45) | Not satisfied: 11 (55) | B: 0 (0) |
| Tuknayat et al. 2021 [2] | — | — | — | 13.7 | 6.258 | — | Excellent: 4 (10) | Xerosis: 14 (35) | |
| Very pleased: 19 (47.5) | Pruritus: 10 (25) |
| Pleased: 16 (40) | |
| Satisfied: 1 (2.5) | |
| Not satisfied: 0 (0) | |
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