Optimisation of a Mouse Model of Cerebral Ischemia-Reperfusion to Address Issues of Survival and Model Reproducibility and Consistency

Figure 6

Comparison of rates of weight change, 24 h, 72 h, 1 w postoperatively. (a) Intergroup comparison: at 2 postoperative time points (72 h, 1 w), there was a statistically significant difference in weight change in the ICA2 group compared to ECA1 and ECA2 groups respectively  < 0.0001,  < 0.0001,  < 0.0001,  < 0.0001, n = 15. Intragroup comparison: no significant difference in the rate of weight change in the ICA2 group at the 2 postoperative time points (24 h, 1 w)  > 0.05,  > 0.05, n = 15 (b) The difference in weight change between the ECA1 group and the ICA2 group at different time points. (c) The difference in weight change between the ECA2 group and the ICA1 group at different time points. Notes: The letters a, b, c, d, e, f, g, h, i, j, k mark the differences between intergroup and intragroup, the letters are different between the two points suggesting that there is a difference and that the difference is statistically significant, the letters are repeated between the two points suggesting that there is no difference.

(a)

(b)

(c)