Hippocampal Mitochondrial Transplantation Alleviates Age-Associated Cognitive Decline via Enhancing Wnt Signaling and Neurogenesis

Figure 1

Restoration of mitochondrial function in the aged hippocampus by mitochondria transplantation. (a) Representative electron microscopic images of isolated mitochondria. (b) Western blots of Tom20 in young mice treated with vehicle, aged mice treated with vehicle, and aged mice treated with mitochondria. (c) ATP levels in the hippocampus of young mice injected with vehicle, aged mice injected with vehicle, and aged mice injected with mitochondria. (d) Mitochondrial complexes I–V activities of young mice treated with vehicle, aged mice treated with vehicle, and aged mice treated with mitochondria. The restoration of Tom20 expression, ATP level, and respiratory complex activity by exogenous mitochondria should be noted. Values represent the mean ± S.E.M. . . Veh, vehicle. Mito, mitochondria.

(a)

(b)

(c)

(d)