Review Article
Modern Treatments and Stem Cell Therapies for Perianal Crohn’s Fistulas
Table 1
Summary of conventional and biological medical treatments of fistulizing CD and reported outcomes.
| Treatment | Studies | Outcome |
| Antibiotics | Brandt et al. [5], Prantera et al. [6]; uncontrolled studies | Symptoms reduction but failed closure | Thia et al. [7] an RCT; AB versus placebo. | No significant difference | Thiopurines | Pearson et al. [8] a meta-analysis; Thio versus placebo | Complete fistula closure or reduction in fistula drainage in 54% of patients | Anti-TNF alpha | | | Infliximab | Present study [9] 5 mg/kg versus 10 mg/kg versus placebo | ≥50% closure; 68% versus 56% versus 26% (, , resp.) | ACCENT II study [10] infliximab versus placebo | Maintenance of complete closure of draining fistula; 36% versus 19% () | Adalimumab | CHARM study [12] adalimumab versus placebo | Complete fistula healing at 56 wks; 33% versus 13% () | ADHERE study [13] | 23% fistula remission, 41% fistula improvement | Certolizumab pegol | Schreiber et al. [14] an RCT; certolizumab pegol versus placebo | Complete closure at 26 weeks; 36% versus 17% () |
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