Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy

Figure 3

Metabolism of azathioprine. Aza: azathioprine; 6-MP: 6-mercaptopurine; TPMT: thiopurine methyltransferase; 6-MMP: 6-methylmercaptopurine; 6-TU: thiouric acid; 6-TG: 6-thioguanine; HPRT: hypoxanthine phosphoribosyl transferase; 6-TGN: thioguanine nucleotide; GMPS: guanosine monophosphate synthetase; 6-TXMP: 6-thioxanthosine monophosphate; IMPDH: inosine-5′-monophosphate dehydrogenase; 6-MMPR: 6-methyl-mercaptopurine ribonucleotide; 6-TIMP: thioinosine monophosphate.