Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy

Figure 4

A diagram of regulatory T cell therapy in autoimmune hepatitis. Patients with autoimmune hepatitis undergo leukapheresis followed by isolation of highly pure, autologous, GMP grade, functional CD4 and regulatory T cells followed by expansion with clinical grade expander beads, IL-2, and rapamycin. These cells can be tested for their purity and stability with flow cytometry and TSDR analysis before infusing back to AIH patients.