Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy

Table 1

Simplified scoring system used for diagnosis of autoimmune hepatitis [17].

Variables	Cut-off	Points
ANA or SMA	≥1; 40	1
	≥1 : 80	2
Or LKM 1	≥1 : 40	2
Or SLA	Positive	1
Ig G	>Upper limit of normal	1
	>1.1x upper limit of normal	2
Liver histology	Compatible with AIH^#	1
	Typical of AIH	2
Absence of viral hepatitis	Yes	2
Exclude other causes of acute liver injury:
(i) Drug induced liver injury (history)
(ii) Acute hepatitis A (check HAV IgM)
(iii) Acute hepatitis E (check HEV IgM)
(iv) Wilson’s disease

ANA: anti-nuclear antibodies; SMA: anti-smooth-muscle antibodies; LKM1: liver/kidney microsomal antibody type 1; SLA: antisoluble liver antigen.
Viral hepatitis: exclusion of viral hepatitis B and hepatitis C. Other viral markers such as Cytomegalovirus, Varicella Zoster virus, Epstein Barr virus, and human immunodeficiency virus (HIV) should be excluded.
Liver Histology.
^#Compatible with AIH: chronic hepatitis with lymphocytic infiltration, without typical features.
Typical of AIH: interface hepatitis, emperipolesis, and hepatic rosette formation.
Definite AIH: a cumulative score ≥ 7.
Probable AIH: a cumulative score = 6.