Microsatellite Instability in Mouse Models of Colorectal Cancer

Figure 1

MSI in the normal colon of the Msh2-KO mouse. (a) Reference pattern of mononucleotide repeat markers uPAR, Bat24, Bat37, Bat59, and Bat64 in a WT mouse. Bat64 shows two alleles. The position of the highest peak in the WT mouse is highlighted with the grey bar and the size is indicated in the top right corner; (b, c) contraction of the repeats in two representative Msh2-KO mice compared to WT. (d) The position and size of the peaks for the size standard ROX.