Diagnostic Value of lncRNAs as Biomarker in Hepatocellular Carcinoma: An Updated Meta-Analysis

Table 3

Summarized results of meta-analysis based on R.

Subgroup analysis	SEN(95CI)	SPE(95CI)	DOR(95CI)	PLR(95CI)	NLR(95CI)	AUC
Hepatocellular carcinoma	0.87(0.838-0.897)	0.829(0.794-0.86)	23.085(20.575-25.901)	4.533(4.239-4.847)	0.176(0.166-0.186)	0.915
LncRNA profiling
Single lncRNA	0.862(0.825-0.892)	0.805(0.76-0.844)	20.027(17.638-22.740)	4.129(3.839-4.441)	0.191(0.179-0.204)	0.902
Multiple lncRNAs	0.898(0.82-0.944)	0.886(0.845-0.916)	43.220(32.833-56.893)	6.736(5.627-8.064)	0.127(0.115-0.140)	0.940
Sample source
Plasma	0.884(0.827-0.924)	0.803(0.732-0.859)	14.132(11.992-16.654)	3.449(3.118-3.815)	0.203(0.187-0.221)	0.911
Serum	0.869(0.824-0.904)	0.856(0.829-0.879)	35.971(30.089-43.002)	6.057(5.504-6.666)	0.160(0.147-0.173)	0.916
Tissue	0.892(0.862-0.916)	0.784(0.421-0.948)	52.000(35.881-75.359)	6.473(5.075-8.256)	0.123(0.099-0.153)	0.887
Sample size
Small sample(<200)	0.832(0.792-0.866)	0.829(0.775-0.883)	18.825(15.341-23.101)	4.065(3.652-4.524)	0.211(0.189-0.236)	0.894
Large sample(⩾200)	0.903(0.856-0.936)	0.83(0.779-0.871)	25.207(21.927-28.979)	4.736(4.343-5.164)	0.162(0.152-0.173)	0.927
Ethnicity
Asian	0.873(0.837-0.902)	0.836(0.796-0.869)	23.549(20.864-26.579)	4.575(4.256-4.917)	0.175(0.166-0.185)	0.919
African	0.868(0.787-0.922)	0.797(0.73-0.851)	21.042(14.488-30.561)	4.293(3.538-5.211)	0.178(0.124-0.255)	0.875

SEN, sensitivity; SPE, specificity; DOR, diagnostic odds ratio; PLR, positive likelihood ratio; NLR, negative likelihood ratio; AUC, area under the curve.