Lymphopenia Is Associated with Gross Target Volumes and Fractions in Hepatocellular Carcinoma Patients Treated with External Beam Radiation Therapy and Also Indicates Worse Overall Survival

Table 2

Univariate and multivariate linear regression associating baseline variables with lymphocyte nadirs during radiation treatment.

Variable	Regression coefficient	95% CI	value
Univariate analysis
Gender	−0.136	−0.294 to 0.022	0.090
Age	0.006	0.001 to 0.011	0.025
KPS	0.003	−0.011 to 0.017	0.681
Child-Pugh	−0.073	−0.141 to −0.004	0.037
BCLC stage	−0.1	−0.179 to −0.02	0.014
Tumor thrombus (yes/no)	−0.169	−0.318 to −0.021	0.026
LNM (yes/no)	−0.186	−0.368 to −0.004	0.045
TACE (yes/no)	−0.015	−0.138 to 0.107	0.805
RFA (yes/no)	0.027	−0.177 to 0.231	0.795
Tumor size (cm)	−0.019	−0.035 to −0.004	0.015
BED	0.007	0.003 to 0.012	0.010
Fractions	−0.016	−0.023 to −0.009	<0.001
Log10GTV	−0.205	−0.238 to −0.127	<0.001
Multivariate analysis
Fractions	−0.029	−0.046 to −0.012	0.001
Log10GTV	−0.195	−0.291 to −0.099	<0.001

CI = confidence interval.