Research Article

Lymphopenia Is Associated with Gross Target Volumes and Fractions in Hepatocellular Carcinoma Patients Treated with External Beam Radiation Therapy and Also Indicates Worse Overall Survival

Table 4

Patient characteristics of conventional fractionationated RT (CFRT), hypofractionated RT (HFRT), and stereotactic body RT (SBRT) group.

CharacteristicCFRT (n = 68)HFRT (n = 58)SBRT (n = 58) value

Gender0.976
Male56 (82.4)47 (81.0)47 (81.0)
Female12 (17.6)11 (19.0)11 (19.0)

Age (y), median (range)57 (32–78)58 (32–87)60 (22–86)0.301
BCLC stage<0.001
A9 (13.2)14 (24.1)34 (58.6)
B31 (45.6)22 (37.9)18 (31.0)
C27 (39.7)20 (34.5)3 (5.2)
MV1 (1.5)2 (3.4)3 (5.2)

HBV0.493
Negative15 (22.1)18 (31.0)14 (24.1)
Positive53 (77.9)40 (69.9)44 (75.9)

Tumor size (cm)<0.001
≤523 (33.8)23 (39.7)47 (81.0)
>545 (66.2)34 (58.6)8 (13.8)
MV01 (1.7)3 (5.2)

Pre-ALC (×109/L), median (range)1.3 (0.2–3.5)1.3 (0.4–2.8)1.4 (0.3–3.5)0.886
Post-ALC (×109/L), median (range)0.4 (0.1–1.4)0.4 (0.1–1.4)0.6 (0.2–2.2)<0.001
Lymphocyte nadir (×109/L), median (range)0.4 (0.1–1.6)0.5 (0.1–1.2)0.7 (0.1–2.6)<0.001
BED (Gy), median (range)64.8 (50.0–84.0)75.0 (58.5–91.1)86.4 (79.0–119.0)<0.001
Fraction number25 (16–35)15 (10–25)6 (5–10)<0.001
GTV (cc), median (range)190.5 (8.0–1711.3)94.0 (2.2–1880.1)15.2 (1.6–126.6)<0.001

MV = missing value.