Canadian Journal of Gastroenterology and Hepatology / 2019 / Article / Tab 4 / Research Article
Lymphopenia Is Associated with Gross Target Volumes and Fractions in Hepatocellular Carcinoma Patients Treated with External Beam Radiation Therapy and Also Indicates Worse Overall Survival Table 4 Patient characteristics of conventional fractionationated RT (CFRT), hypofractionated RT (HFRT), and stereotactic body RT (SBRT) group.
Characteristic CFRT (n = 68) HFRT (n = 58) SBRT (n = 58) valueGender 0.976 Male 56 (82.4) 47 (81.0) 47 (81.0) Female 12 (17.6) 11 (19.0) 11 (19.0) Age (y), median (range) 57 (32–78) 58 (32–87) 60 (22–86) 0.301 BCLC stage <0.001 A 9 (13.2) 14 (24.1) 34 (58.6) B 31 (45.6) 22 (37.9) 18 (31.0) C 27 (39.7) 20 (34.5) 3 (5.2) MV 1 (1.5) 2 (3.4) 3 (5.2) HBV 0.493 Negative 15 (22.1) 18 (31.0) 14 (24.1) Positive 53 (77.9) 40 (69.9) 44 (75.9) Tumor size (cm) <0.001 ≤5 23 (33.8) 23 (39.7) 47 (81.0) >5 45 (66.2) 34 (58.6) 8 (13.8) MV 0 1 (1.7) 3 (5.2) Pre-ALC (×109 /L), median (range) 1.3 (0.2–3.5) 1.3 (0.4–2.8) 1.4 (0.3–3.5) 0.886 Post-ALC (×109 /L), median (range) 0.4 (0.1–1.4) 0.4 (0.1–1.4) 0.6 (0.2–2.2) <0.001 Lymphocyte nadir (×109 /L), median (range) 0.4 (0.1–1.6) 0.5 (0.1–1.2) 0.7 (0.1–2.6) <0.001 BED (Gy), median (range) 64.8 (50.0–84.0) 75.0 (58.5–91.1) 86.4 (79.0–119.0) <0.001 Fraction number 25 (16–35) 15 (10–25) 6 (5–10) <0.001 GTV (cc), median (range) 190.5 (8.0–1711.3) 94.0 (2.2–1880.1) 15.2 (1.6–126.6) <0.001
MV = missing value.