A Drug-Induced Acute Pancreatitis Retrospective Study

Table 3

Drug-induced acute pancreatitis causative drugs (number of hospitalizations) classified according to the evidence-level classification system proposed by Badalov and colleagues [12] (n = 90).

Class Ia^a	Class Ib^b	Class II^c	Class III^d	Class IV^e
5-Fluorouracil (2)	N/A	Azathioprine (7)	Amoxicillin–clavulanic acid(2)	Azithromycin	Lurasidone
Atorvastatin (6)		Codeine (4)	Cisplatin (3)	Canagliflozin	Metformin
Bortezomib (2)		Hydrochlorothiazide (5)	Dexamethasone (2)	Capecitabine	Methotrexate
Nilotinib (2)			Mercaptopurine (3)	Carbamazepine	Metronidazole
Rosuvastatin (4)			Mesalazine (3)	Celecoxib	Minocycline
Triamcinolone (3)			Saxagliptin (2)	Certolizumab	Morphine
			Sitagliptin (2)	Clarithromycin	Naproxen
			Sitagliptin–metformin(2)	Clindamycin	Pazopanib
			Trimethoprim–sulfamethoxazole(2)	Cyclophosphamide-doxorubicin	Perindopril
			Venlafaxine (2)	Cyclophosphamide-vincristine-doxorubicin	Phenytoin
				Diclofenac	Rifampin
				Ezetimibe	Saxagliptin-metformin
				Ibuprofen	Sertraline
				Immediate-release morphine	Simvastatin sulfasalazine
				Losartan/hydrochlorothiazide	Tamoxifen
					Tocilizumab

^aClass Ia included drugs for which at least one case of rechallenge has been described and all potential causes of acute pancreatitis have been excluded. ^bClass Ib included drugs for which at least one case of rechallenge has been described and the potential causes of acute pancreatitis have not been excluded. ^cClass II included drugs found in at least four evidences. ^dClass III included drugs found in at least two evidences. ^eClass IV included drugs found in at least one evidence. Each individual medication included in this class was implicated in only 1 case. The asterisk () means that the drugs are in association. The drugs in bold are not present in the systematic review of Badalov et al. (2007).