| | Variables | HCC on NAFLD (n = 56) | HCC on ALD (n = 173) | HCC on HBV (n = 393) | value |
| | Demographic and clinical | | Age (years), mean (SD) | 68.0 (10.9) | 64.1 (9.4) | 56.2 (10.4) | <0.001 | | Male gender, n (%) | 35 (62.5%) | 167 (96.5%) | 312 (79.4%) | <0.001 | | Body mass index (kg/m2), mean (SD) | 22.7 (6.7) | 22.6 (6.5) | 22.4 (6.5) | 0.860 | | Tobacco, n (%) | 17 (30.4%) | 87 (50.3%) | 137 (34.9%) | 0.001 | | Metabolic risk factors | | Diabetes, n (%) | 27 (48.2%) | 58 (33.5%) | 77 (19.6%) | <0.001 | | Hypertension, n (%) | 24 (42.9%) | 47 (27.2%) | 86 (21.9%) | 0.003 | | Blood glucose (mg/dL), mean (SD) | 151.5 (67.5) | 133.5 (50.8) | 126.0 (55.6) | 0.005 | | LDL cholesterol (mg/dL), mean (SD) | 89.1 (50.4) | 83.1 (54.5) | 91.5 (51.1) | 0.202 | | HDL cholesterol (mg/dL), mean (SD) | 39.5 (14.5) | 40.8 (16.9) | 42.1 (18.6) | 0.594 | | Triglycerides (mg/dL), mean (SD) | 101.6 (48.3) | 87.8 (42.7) | 92.1 (54.8) | 0.322 | | Liver function | | Bilirubin (mg/dL), mean (SD) | 1.1 (0.9) | 2.1 (2.7) | 3.0 (7.9) | 0.720 | | Albumin (mg/dL), mean (SD) | 3.6 (0.6) | 3.3 (0.7) | 3.4 (0.7) | 0.003 | | INR, mean (SD) | 1.1 (0.4) | 1.2 (0.6) | 1.3 (1.0) | 0.549 | | Liver cirrhosis, n (%) | 42 (75.0%) | 161 (93.1%) | 356 (90.6%) | <0.001 | | Hepatic encephalopathy, n (%) | 0 (0.0%) | 5 (2.9%) | 11 (2.8%) | 0.443 | | Ascites, n (%) | 18 (32.1%) | 97 (56.1%) | 185 (47.1%) | 0.006 | | CTP score, mean (SD) | 6.2 (1.4) | 6.9 (1.6) | 6.7 (1.8) | 0.014 | | CTP class A, n (%) | 39 (69.6%) | 82 (47.4%) | 215 (54.7%) | 0.013 | | CTP class B, n (%) | 16 (28.6%) | 74 (42.8%) | 145 (36.9%) | 0.136 | | CTP class C, n (%) | 1 (1.8%) | 17 (9.8%) | 33 (8.4%) | 0.158 | | MELD score, mean (SD) | 9.1 (4.1) | 12.0 (7.3) | 11.3 (6.9) | 0.021 |
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