Canadian Journal of Gastroenterology and Hepatology / 2020 / Article / Tab 1 / Review Article
Regulating Intestinal Microbiota in the Prevention and Treatment of Alcohol-Related Liver Disease Table 1 Animal experimental studies on the treatment of ALD with probiotics, prebiotics, and synbiotics.
Study Object Types of drug Outcomes Forsyth et al. [18 ] Alcoholic steatohepatitis male Sprague-Dawley rats Lactobacillus rhamnosus (LGG)Liver steatosis severity reduced Chang et al. [19 ] Male wild type rats with acute alcohol-related liver disease VSL#3 (a mixture of probiotics such as Lactobacillus acidophilus and Lactobacillus plantarum ) Increased intestinal permeability (decreased plasma endotoxin and TNFα levels) Bang et al. [15 ] Alcohol-related liver disease C57BL/6 mice Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052Reduced inflammation of the liver (TLR4 expression decreased) Grander et al. [20 ] C57BL/6 mice with alcoholic steatohepatitis Colistin Increased gut barrier integrity (relative abundance of A. muciniphila and mucin is increased) Tang et al. [21 ] Male alcohol-related liver disease Sprague- Dawley rats Oats (prebiotics) Reduced oxidative stress (NOS, NO protein carbonylation, and nitrotyrosination) and increased gut barrier integrity (integrity of actin cytoskeleton and tight junction) Yan et al. [22 ] Alcohol-related liver disease mice Fructooligosaccharide (FOS) Improvement of the degree of liver inflammation (recovery of the level of antimicrobial protein Reg3g and reduction of intestinal bacterial overgrowth) Ferrere et al. [23 ] Mice fed by alcohol Prebiotic pectin Relative abundance of bacteroides was increased, improvement of the severity of steatosis, and reduction of inflammation in the liver