Treatment Effect of a Vascular-Disrupting Agent Dynamically Monitored by DWI: An Animal Experimental Study

Figure 1

Findings in the M410 group. At all-time points, the tumor was hypointense on T1-weighted imaging (T1WI) and heterogeneously hyperintense on T2-weighted imaging (T2WI). At 4 h and 1 day after VDA treatment, the diffused weighted-imaging (DWI) signal of the tumor increased compared with the baseline, and the apparent diffusion coefficient (ADC) values of both the entire tumor and the solid component of the tumor decreased. At 4–14 days after treatment, the DWI signal of the tumor gradually decreased, and the ADC value of the entire tumor gradually increased compared with day 1. The ADC value of the solid component of the tumor first increased on day 4, then gradually decreased on day 7 and day 14 compared with that on day 1.