Research Article

Prognostic Analysis of Different Metastatic Patterns in Invasive Intraductal Papillary Mucinous Neoplasm: A Surveillance, Epidemiology, and End Results Database Analysis

Table 2

Multivariate analyses of overall survival and pancreatic cancer-specific survival in patients with intraductal papillary mucinous neoplasm.

FeaturesOSCSS
HR (95%CI) valueHR (95%CI) value

Metastasis
 Isolated liver metastasis1 (reference)1 (reference)
 Isolated lung metastasis0.681 (0.564–0.822)<0.0010.682 (0.545–0.852)0.001
 Isolated bone metastasis0.469 (0.280–0.786)0.0040.551 (0.299–1.016)0.056
 Multiple1.325 (1.098–1.600)0.0031.331 (1.080–1.640)0.007
 Other organ metastasis0.784 (0.659–0.933)0.0060.785 (0.646–0.953)0.015

Gender
 Male1 (reference)1 (reference)
 Female1.014 (0.914–1.124)0.7961.007 (0.892–1.137)0.909

Age (y)
 <601 (reference)1 (reference)
 ≥601.347 (1.186–1.530)<0.0011.271 (1.102–1.467)0.001

Race
 White1 (reference)1 (reference)
 Black0.950 (0.806–1.120)0.5420.884 (0.728–1.073)0.213
 Yellow0.766 (0.639–0.920)0.0040.746 (0.605–0.919)0.006

Marital
 Married1 (reference)1 (reference)
 Unmarried1.107 (0.992–1.236)0.0691.129 (0.991–1.285)0.067
 Unknown1.098 (0.867–1.391)0.4391.082 (0.828–1.414)0.563

Primary Site
 Head1 (reference)1 (reference)
 Body/tail1.079 (0.954–1.221)0.2281.155 (0.997–1.339)0.055
 Others1.086 (0.955–1.234)0.2091.117 (0.960–1.299)0.153

Surgery
 No1 (reference)1 (reference)
 Yes0.201 (0.171–0.238)<0.0010.187 (0.153–0.230)<0.001

Chemotherapy
 No1 (reference)1 (reference)
 Yes0.594 (0.530–0.666)<0.0010.584 (0.511–0.668)<0.001

Radiotherapy
 No1 (reference)1 (reference)
 Yes1.079 (0.916–1.270)3641.168 (0.962–1.419)0.116

Grade
 I1 (reference)1 (reference)
 II1.220 (0.974–1.528)0.0841.189 (0.909–1.555)0.207
 III1.357 (1.045–1.762)0.0221.315 (0.971–1.782)0.077
 IV1.246 (0.606–2.559)0.5491.059 (0.385–2.909)0.912
 Unknown0.939 (0.771–1.145)0.5360.892 (0.703–1.132)0.347

For the Cox proportional model of OS, the value of test proportional hazards assumption was 0.1205 (). For the Cox proportional model of CSS, the value of test proportional hazards assumption was 0.0521 ().