Clinical Features and Outcomes of Primary Sclerosing Cholangitis in the Highly Admixed Brazilian Population
Table 2
Factors associated with adverse outcomes, either liver transplantation or death, in patients with PSC.
Variables
Univariate
Multivariable
HR (95% CI)
value
HR (95% CI)
value
Female sex
0.82 (0.50–1.33)
0.422
Age at diagnosis (years)
1.01 (0.99–1.02)
0.399
Baseline clinical features
Asymptomatic
0.24 (0.09–0.59)
0.002
Pruritus
2.37 (1.45–3.88)
0.001
1.88 (1.09–3.23)
0.023
Fatigue
1.61 (0.96–2.71)
0.071
Weight loss
1.95 (1.17–3.25)
0.011
Laboratory at baseline (x ULN)
Alkaline phosphatase
1.02 (1.00–1.05)
0.043
Total bilirubin
1.10 (1.07–1.14)
<0.001
1.08 (1.05–1.12)
<0.001
Small duct PSC
0.69 (0.31–1.53)
0.369
IBD
1.39 (0.81–2.39)
0.229
UDCA treatment
0.70 (0.40–1.23)
0.221
Advanced PSC
5.89 (2.91–11.93)
<0.001
6.12 (2.73–13.71)
<0.001
Data are expressed as absolute number (percentage) or median (interquartile range). CI, confidence interval; HR, hazard ratio; IBD, inflammatory bowel disease; PSC, primary sclerosing cholangitis; UDCA, ursodeoxycholic acid; ULN, upper limit of normal. Cox regression was performed.
