Research Article

LncRNA ELF3-AS1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma

Table 2

Correlation between ELF3-AS1 expression and clinical characteristics of HCC.

CharacteristicLow expression of ELF3-AS1High expression of ELF3-AS1

n187187
T stage, n (%)0.002
T1107 (28.8%)76 (20.5%)
T236 (9.7%)59 (15.9%)
T338 (10.2%)42 (11.3%)
T43 (0.8%)10 (2.7%)

N stage, n (%)0.623
N0124 (48.1%)130 (50.4%)
N11 (0.4%)3 (1.2%)

M stage, n (%)0.124
M0129 (47.4%)139 (51.1%)
M10 (0%)4 (1.5%)

Pathologic stage, n (%)0.003
 Stage I102 (29.1%)71 (20.3%)
 Stage II33 (9.4%)54 (15.4%)
 Stage III38 (10.9%)47 (13.4%)
 Stage IV1 (0.3%)4 (1.1%)

Tumor status, n (%)0.101
 Tumor free110 (31%)92 (25.9%)
 With tumor69 (19.4%)84 (23.7%)

Gender, n (%)0.008
 Female48 (12.8%)73 (19.5%)
 Male139 (37.2%)114 (30.5%)

Race, n (%)0.037
 Asian70 (19.3%)90 (24.9%)
 Black or African American12 (3.3%)5 (1.4%)
 White100 (27.6%)85 (23.5%)

Age, n (%)0.277
 ≤6083 (22.3%)94 (25.2%)
 >60104 (27.9%)92 (24.7%)

Weight, n (%)0.272
 ≤7088 (25.4%)96 (27.7%)
 >7088 (25.4%)74 (21.4%)

Height, n (%)0.130
 <17094 (27.6%)107 (31.4%)
 ≥17078 (22.9%)62 (18.2%)
BMI, n (%)0.296
 ≤2584 (24.9%)93 (27.6%)
 >2586 (25.5%)74 (22%)

Residual tumor, n (%)0.004
R0172 (49.9%)155 (44.9%)
R13 (0.9%)14 (4.1%)
R20 (0%)1 (0.3%)

Histologic grade, n (%)< 0.001
G141 (11.1%)14 (3.8%)
G294 (25.5%)84 (22.8%)
G347 (12.7%)77 (20.9%)
G42 (0.5%)10 (2.7%)

Adjacent hepatic tissue inflammation, n (%)0.025
 None73 (30.8%)45 (19%)
 Mild44 (18.6%)57 (24.1%)
 Severe10 (4.2%)8 (3.4%)

Albumin(g/dl), n (%)0.982
 <3.536 (12%)33 (11%)
 ≥3.5118 (39.3%)113 (37.7%)

AFP (ng/ml), n (%)< 0.001
 ≤400119 (42.5%)96 (34.3%)
 >40018 (6.4%)47 (16.8%)

Prothrombin time, n (%)0.889
 ≤4104 (35%)104 (35%)
 >446 (15.5%)43 (14.5%)

Child-Pugh grade, n (%)0.176
A110 (45.6%)109 (45.2%)
B14 (5.8%)7 (2.9%)
C1 (0.4%)0 (0%)

Fibrosis Ishak score, n (%)0.526
 043 (20%)32 (14.9%)
 1/213 (6%)18 (8.4%)
 3/415 (7%)13 (6%)
 5/645 (20.9%)36 (16.7%)

Vascular invasion, n (%)0.037
 No114 (35.8%)94 (29.6%)
 Yes46 (14.5%)64 (20.1%)

Age, median (IQR)63 (53, 69)60 (51, 68)0.239