Review Article

Friend or Foe? Spontaneous Portosystemic Shunts in Cirrhosis—Current Understanding and Future Prospects

Table 1

Overview of recent studies on efficacy and safety of portosystemic shunt embolization for recurrent hepatic encephalopthy.

Authors, yearnTypes of shuntTechnique; success rateFollow-upComplicationsEfficacy; comments

Mukund et al, 20127Splenorenal-7BRTO; 86%4 months (mean)2 early complications (hepatic and renal dysfunction with bacteremia)-responded to medical managementHE improvement: 100%; retrospective, single-centre study, small sample size, limited follow-up; no endoscopic or long-term imaging data
Laleman et al, 201337Splenorenal-20
Paraumbilical-9
Mesocaval-7
Mesorenal 1
CARTO, PARTO; 100%697 days (mean)8 early complications-7 mild and 1 capsular bleed
De novo EV-2, EV bleeding-1, nonfatal
Ascites-no significant difference
PVT: 4 (11%; 1 in PV, 3 in one branch)
HE improvement: short-term (100 days): 59.4%
Long-term (2 years): 48.6%;
Retrospective, multicentre study
Lynn et al, 201320Splenorenal-12
Rest-other types
CARTO, PARTO; 100%12 months (median)2 early complications-1 mild, 1 cholangitis
De novo EV-1
Ascites-6 (4 requiring paracentesis)
HE improvement:
Short-term (1–4 months): 100%
Long-term (6–12 months): 92%
An et al, 201417Splenorenal-14
Paraumbilical– 3
CARTO, PARTO; 100%19 months (median)No procedure-related complications
Ascites–3 (mild)
EV: 3, no GIB, no PVT
Recurrence of HE for 2 years:
39.9% (embolized) versus 79.9% (control)
Naeshiro et al, 201414Splenorenal-3
Gastrorenal-4
Mesocaval-5
Portocaval-2
BRTO, CARTO; 92.9%27 months (median)No serious procedure-related complications
EV: worsening at 3 months (21%), worsening at 24 months (29%)
GIB: 14%
HE disappearance in 1–2 weeks: 93%
Inoue et al, 201419Splenorenal-19BRTO; 100%28 months (mean)No serious procedure-related complications
Ascites: 21%
HE improvement: 100%
Philips et al, 201721Splenorenal-17
Mesocaval-7
Rest-other types
CARTO, PARTO,
SSO; 95.2%
1–9 months1 mortality-hemoperitoneum
EV : no significant increase
GIB: 1 nonfatal, ascites: no significant increase
HE improvement:
Short-term follow-up: 71%
Long-term: 23%
Philips et al, 202045Splenorenal-25
Mesocaval-4
Paraumbilical-4
Rest-other types
BRTO, CARTO, PARTO,
CAATO; 100%
18 monthsTwo study groups-early (first episode of HE) and late (recurrent HE) shunt embolization
Ascites, GIB, recurrence of HE, PVT lower in early shunt embolization group
Recurrence of HE%-4.5 in the early embolization group versus 28.6% in the late embolization group, at 9 months

BRTO: balloon-occluded retrograde transvenous obliteration, CARTO: coil-assisted retrograde transvenous obliteration, PARTO: plug-assisted retrograde transvenous obliteration, SSO: surgical shunt occlusion, CAATO: coil-assisted antegrade transvenous obliteration, EV: esophageal varices, GIB: gastrointestinal bleeding, HE: hepatic encephalopathy, and PVT: portal vein thrombosis.