Systemic Overexpression of GDF5 in Adipocytes but Not Hepatocytes Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver in Mice

Figure 1

Morphological changes in the livers of GDF5 transgenic (TG) mice after HFD feeding for 10 weeks. (a) Comparison of liver sizes in TG mice and WT mice. (b) Body weights and liver weights of TG and WT mice. (c) Normalization of liver weight to body weight of TG and WT mice. (d) Oil Red O staining of TG mouse livers (scale: 100 μm). (e) Oil Red O staining of WT mouse livers (scale: 100 μm). (f) Quantitative analysis of lipid droplets in hepatocytes. (g) HE staining of TG mouse livers (scale: 100 μm). (h) HE staining of WT mouse livers (scale: 100 µm) (: ; : ).

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