GLP-1 Receptor Agonist Effects on Lipid and Liver Profiles in Patients with Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis

Table 2

Summary of findings.

Absolute effect WMD (95% CI)	No. of studies	Study design	Risk of bias	Inconsistency	Indirectness	Imprecision	Publication bias	Effect size	GRADE quality
Effects of GLP-1 on lipid profile
TG
−7.07 [−17.51, 3.37]	9	RCT	−1	−1^¥	0	−2^†	0	+1
TC
−1.17 [−5.25, 2.91]	9	RCT	−1	0	0	−1	0	0
HDL-c
0.97 [−1.63, 3.58]	8	RCT	−1	0	0	−1^¶	0	0
LDL-c
−1.67 [−10.08, 6.74]	8	RCT	−1	0	0	−2	0	0
Effects of GLP-1 on liver enzymes
AST
−2.95 [−7.26, 1.37]	12	RCT	−1	0	0	−2	0	0	(low)
ALT
−10.14 [−15.84, −4.44]	12	RCT	−1	0	0	−1	0	+1^‡	(moderate)

The symbols show the quality of evidence. Abbreviations: WMD, weighted mean difference; CI, confidence interval; RCT, randomized controlled trial; TG, triglycerides; TC, total cholesterol; HDL-c, high-density lipoprotein-cholesterol; LDL-c, low-density lipoprotein-cholesterol, AST, aspartate aminotransfrase; ALT, alanine aminotransfrase. Downgraded one level as the moderate risk of bias. ^¶Downgraded one level as the confidence interval was moderate. ^†Downgraded two levels as the number of studies was <5 and imprecision was considerable. ^‡Upgraded one level due to considerable effect size. ^¥Downgraded one level as the statistical heterogeneity was >50%.