Comparison of General and Liver-Specific Prognostic Scores in Their Ability to Predict Mortality in Cirrhotic Patients Admitted to the Intensive Care Unit
Table 1
Demographics, clinical features, and outcomes of cirrhotic patients admitted to the ICU.
Characteristics
All patients (n = 382)
Patients with ACLF (n = 178)
Cirrhosis with AD (n = 204)
Age (years)
67.3 ± 10.6
58.2 ± 24.7
62.4 ± 20.8
Male sex
280 (73%)
133 (74.7%)
147 (72.1%)
Ascites
321 (84%)
154 (86.5%)
167 (81%)
Hepatic encephalopathy
211 (55%)
110 (61.7%)
101 (49.5%)
Variceal bleeding
24 (6%)
12 (6.7%)
12 (5.9%)
Bacterial infections/sepsis
233 (61%)
98 (55%)
135 (66%)
Acute kidney injury
123 (32%)
80 (45%)
43 (21%)
ACLF by CLIF-C criteria
178 (47%)
(i) Grade I
90 (24%)
(ii) Grade II
36 (9%)
(iii) Grade III
52 (14%)
ACLF by NACSELD criteria
33 (9%)
Serum sodium (mEq/L)1
136 (132–140) 109–157
137 (131–140) 109–157
136 (132–140) 109–155
Serum creatinine (g/dl)1
1.0 (0.7–1.6) 0.3–8.4
1.4 (0.87–2.5) 0.4–8.4
0.9 (0.6–1.2) 0.3–3.5
Serum albumin (mg/dl)1
2.5 (2.2–2.9) 0.4–4.4
2.5 (2.1–2.9) 1.0–4.2
2.6 (2.3–2.9) 0.4–4.4
Serum bilirubin (mg/dl)1
2.0 (1.2–4.2) 0.4–36.7
2.3 (1.2–5.3) 0.4–36.7
2.0 (1.1–3.10) 0.4–27
INR1
1.7 (1.4–2.1) 0.51–13.44
1.87 (1.4–2.3)0.93–12.7
1.6 (1.4–2.0) 0.5–3.4
Leukocyte count (109/L)1
7,330 (5,060–11,030) 1,070–45,090
8,670 (6,460–13,722) 1,070–45,090
6,545 (4,360–6,545) 1,140–24,120
MELD-Na
22 ± 8
SOFA
4 ± 3
CLIF-SOFA
5 ± 3
CLIF-C OF
8 ± 2
CLIF-C ACLF
48 + 12
CLIF-C AD
57 + 9
ICU length of stay1
4.0 (2.0–9.0) 0.8–51.0
5 (2–10) 1.0–51.0
3.0 (1–6) 1.0–29.0
Hospital length of stay1
11.0 (8.0–18.0) 1.0–103.0
16.5 (9.0–12.5) 1.0–103.0
10 (7–16) 1.0–64.0
Mortality
118 (30.9%)
95 (53.4%)
23 (11.3%)
1Expressed by median (25th–75th)/min–max; ACLF, acute-on-chronic liver failure; CLIF-C, Chronic Liver Failure Consortium; NACSELD, North American Consortium for the Study of End-Stage Liver Disease; MELD, Model for End-Stage Liver Disease; SOFA, Sequential Organ Failure Assessment; OF, organ failure; AD, acute decompensation; ICU, intensive care unit.
