Canadian Journal of Gastroenterology and Hepatology

Research Article

Comparison of General and Liver-Specific Prognostic Scores in Their Ability to Predict Mortality in Cirrhotic Patients Admitted to the Intensive Care Unit

Table 3

Performance of prognostic scores in cirrhotic patients admitted to the ICU.


Score	AUC	Standard error	95% confidence interval¹	values

All patients (n = 382)
CTP	0.701	0.027	0.648–0.754	<0.001
APACHE II	0.695	0.032	0.632–0.759	<0.001
MELD	0.727	0.030	0.669–0.785	<0.001
MELD-Na	0.729	0.029	0.670–0.784	<0.001
MESO index	0.723	0.030	0.665–0.781	<0.001
iMELD	0.640	0.033	0.576–0.705	<0.001
SOFA	0.753	0.027	0.708–0.796	<0.001
CLIF-SOFA	0.776	0.0269	0.724–0.827	<0.001
CLIF-C OF	0.807	0.025	0.758–0.855	<0.001
CCI	0.627	0.029	0.571–0.683	<0.001
Patients with ACLF (n = 178)
CTP	0.662	0.041	0.581–0.743	0.002
APACHE II	0.674	0.042	0.592–0.755	<0.001
MELD	0.647	0.041	0.566–0.729	0.01
MELD-Na	0.638	0.041	0.557–0.719	0.01
MESO index	0.633	0.041	0.552–0.714	0.02
iMELD	0.540	0.043	0.455–0.625	0.27
SOFA	0.677	0.039	0.600–0.754	0.001
CLIF-SOFA	0.698	0.039	0.622–0.773	<0.001
CLIF-C OF	0.749	0.036	0.679–0.820	<0.001
CLIF-C ACLF	0.665	0.041	0.585–0.745	<0.001
Patients with AD of cirrhosis (n = 204)
CTP	0.650	0.060	0.532–0.768	0.10
APACHE II	0.543	0.083	0.380–0.707	0.52
MELD	0.650	0.072	0.510–0.790	0.06
MELD-Na	0.676	0.065	0.549–0.803	0.02
MESO index	0.654	0.070	0.519–0.790	0.04
iMELD	0.682	0.077	0.532–0.832	0.02
SOFA	0.715	0.063	0.592–0.837	0.008
CLIF-SOFA	0.716	0.062	0.595–0.837	0.008
CLIF-C AD	0.695	0.065	0.569–0.822	0.001

¹Asymptotic normal 95% CI; AD, acute decompensation; ACLF, acute-on-chronic liver failure; CLIF-C, Chronic Liver Failure Consortium; NACSELD, North American Consortium for the Study of End-Stage Liver Disease; CCI, Charlson comorbidities index; APACHE II, Acute Physiology and Chronic Health Evaluation II; MELD, Model for End-Stage Liver Disease; MELD-Na, sodium MELD; MESO index, MELD to serum sodium ratio index; iMELD, integrated-MELD; CTP, Child–Turcotte–Pugh; SOFA, Sequential Organ Failure Assessment; CLIF-SOFA, CLIF Sequential Organ Failure Assessment; CLIF-C OF, CLIF-C organ failure; CLIF-C ACLF, CLIF acute-on-chronic liver failure; CLIF-C AD, CLIF-C acute decompensation.