Comparison of General and Liver-Specific Prognostic Scores in Their Ability to Predict Mortality in Cirrhotic Patients Admitted to the Intensive Care Unit
Table 4
Performance of different prognostic scores in predicting mortality using the optimal cut-off point in all patients, patients with ACLF (CLIF-C ACLF) and patients with AD of cirrhosis (CLIF-C AD).
Score
Cut-off point
Youden index
Sens1 (%)
Spec1 (%)
PPV1
NPV1
LR+
LR−
APACHE II
17
0.321
44.6 (35.6–56.9)
87.6 (82.6–91.3)
63.6 (52.5–73.5)
76.4 (70.8–81.1)
3.6
0.63
CTP
10
0.296
64.4 (55.4–72.5)
65.2 (59.2–70.6)
45.2 (37.9–52.8)
80.4 (74.5–85.1)
1.9
0.55
SOFA
4
0.378
70.3 (61.6–72.8)
67.4 (61.6–72.8)
49.1 (41.7–56.7)
83.6 (78.0–87.9)
2.2
0.44
CLIF-SOFA
5
0.414
65.3 (56.3–73.2)
74.1 (70.6–80.9)
55.0 (46.7–63.0)
83.1 (77.8–87.3)
2.7
0.46
CLIF-C OF
8
0.469
67.0 (58.1–74.8)
79.9 (74.7–84.3)
59.9 (51.3–67.8)
84.4 (79.4–88.4)
3.3
0.41
MELD
23.2
0.379
65.3 (56.3–73.2)
76.1 (70.6–80.9)
55.0 (46.-63.0)
83.1 (77.8–87.3)
2.7
0.46
MELD-Na
27.2
0.367
50.9 (41.9–59.7)
85.8 (81.1–89.5)
61.9 (51.9–70.9)
79.4 (74.3–83.7)
3.6
0.57
iMELD
47
0.296
52.5 (43.6–61.3)
77.0 (71.5–81.7)
50.8 (42.1–59.5)
78.2 (72.8–82.8)
2.3
0.62
MESO index
1.8
0.404
54.2 (45.3–63.0)
85.1 (80.2–88.9)
62.1 (52.5–70.9)
80.4 (75,4–84.7)
3.6
0.54
CCI
4
0.259
89.7 (82.9–94.0)
36.1 (30.6–42.1)
38.5 (32.9–44.4)
88.8 (81.4–93.5)
1.4
0.28
CLIF-C ACLF2
54.6
0.296
44.2 (34.6–54.2)
84.2 (74.7–90.5)
76.4 (63.7–85.6)
56.6 (47.7–65.0)
2.8
0.66
CLIF-C AD3
62.9
0.394
60.9 (40.8–77.8)
78.0 (71.3–81.4)
26.4 (16.4–39.6)
93.9 (88.8–96.8)
2.8
0.50
1Data expressed in % and 95% CI; 2only patients with ACLF (N = 178); 3only patients with AD of cirrhosis (N = 204). Sens: sensitivity; Spec: specificity; PPV: positive predictive value; NPV: negative predictive value; LR+: likelihood ratio positive; LR−: likelihood ratio negative.
