Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats

Table 1

Effects of different doses of APAP on serum levels of the liver enzymes (ALT and AST).

Group	ALT (U/L)	AST (U/L)
NS, 10 ml/kg	58.75 ± 23.1	134.20 ± 32.03
APAP, 640 mg/kg	58.00 ± 19.4^cd	134.65 ± 35.02^cd
APAP, 1000 mg/kg	118.50 ± 30.9^abd	333.50 ± 25.03^abd
APAP, 2000 mg/kg	151.95 ± 33.9^abc	390.05 ± 30.03^abc

Note. Results are expressed as mean ± SEM; compared with ^a10 ml/kg NS, ^b640 mg/kg APAP, ^c1000 mg/kg APAP, and ^d2000 mg/kg APAP. . ALT: alanine aminotransferase, APAP: acetaminophen, AST: aspartate aminotransferase, mg/kg: milligram per kilogram, NS: normal saline, SEM: standard error of mean, and U/L: units per liter.