Canadian Journal of Gastroenterology and Hepatology

Research Article

Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats

Table 2

Effects of crude extracts and solvent fractions of the 80% methanol extract of C. africana stem bark on serum levels of the liver enzymes and TB of rats orally administered 2 g/kg APAP (mean ± SEM).


Group	ALT (U/L)	AST (U/L)	ALP (U/L)	TB (mg/dL)

Normal control	101.57 ± 45.88	218.30 ± 73.18	118.00 ± 42.31	0.09 ± 0.02
Negative control	227.80 ± 40.80^a	417.73 ± 67.10^a	248.33 ± 34.55^a	0.19 ± 0.05^a
100 mg/kg, CAME	110.47 ± 35.18^b,d,e,f (92.9)	347.53 ± 70.28^b,d,e (35.2)	201.00 ± 44.65^b,d,e,f (36.3)	0.15 ± 0.01^b (40)
200 mg/kg, CAME	108.62 ± 40.72^b,c,e,g (94.4)	292.23 ± 63.38^b,c,e (62.9)	225.50 ± 42.31^b,c,e,g (17.5)	0.11 ± 0.01^b,g (80)
400 mg/kg, CAME	102.75 ± 39.74^b,c,d,h (99.1)	254.33 ± 53.20^b,c,d (81.9)	228.50 ± 32.30^b,c,d (15.2)	0.14 ± 0.01^b (50)
100 mg/kg, CAAE	121.96 ± 35.54^b (83.8)	324.77 ± 73.18^b,g,h (46.6)	248.00 ± 34.55^b,g,h (0.3)	0.11 ± 0.01^b (80)
200 mg/kg, CAAE	178.95 ± 56.19^b (38.7)	261.45 ± 80.68^b,f,h (78.4)	245.00 ± 40.33^b,f,h (2.6)	0.15 ± 0.01^b (40)
400 mg/kg, CAAE	153.15 ± 39.74^b (59.1)	254.93 ± 71.53^b,f,g (81.6)	219.67 ± 44.50^b,f,g (22)	0.13 ± 0.02^b (60)
400 mg/kg, CAAF	113.50 ± 56.20^b,j (90.5)	263.38 ± 63.38^b,j (77.4)	248.00 ± 37.64^b (0.3)	0.13 ± 0.01^b (60)
400 mg/kg, CABF	116.80 ± 45.88^b (87.9)	305.58 ± 54.30^b (56.2)	193.67 ± 33.13^b,i (41.9)	0.11 ± 0.02^b,i,k (80)
400 mg/kg, CACF	103.10 ± 61.44^b,i,j (98.8)	242.00 ± 71.27^b,i,j (88.1)	128.50 ± 50.10^b,i,j (91.9)	0.13 ± 0.02^b,j (60)
100 mg/kg, silymarin	98.50 ± 45.88 ^{b,c,d,e,f,g,h,i,j,k} (102.4)	241.75 ± 89.62^{b,c,d,e,f,g,h,i,j,k} (88.2)	177.67 ± 34.55^{b,c,d,e,f,g,h,i,j,k} (54.2)	0.12 ± 0.01^{b,c,d,e,f,g,h,i,j,k} (70)

Compared with ^anormal control, ^bnegative control, ^cCAME100, ^dCAME200, ^eCAME400, ^fCAAE100, ^gCAAE200, ^hCAAE400, ⁱCAAF, ^jCABF, and ^kCACF. . ALP: alkaline phosphatase, ALT: alanine aminotransferase, AST: aspartate aminotransferase, CAAE: aqueous extract of Cordia africana, CAAF: aqueous fraction of Cordia africana, CABF: butanol fraction of Cordia africana, CACF: chloroform fraction of Cordia africana, CAME: 80% methanol extract of Cordia africana, g/kg: gram per kilogram, mg/dl: milligram per deciliter, mg/kg: milligram per kilogram, TB: total bilirubin, and U/L: units per liter.