Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats
Table 3
Effects of crude extracts and solvent fractions of the 80% methanol extract of C. africana stem bark on lipid profiles of rats orally administered 2 g/kg APAP (mean ± SEM).
Group
HDL (mg/dL)
LDL (mg/dL)
TC (mg/dL)
TGs (mg/dL)
Normal control
23.13 ± 1.65
8.40 ± 2.05
38.60 ± 4.02
61.55 ± 14.02
Negative control
19.90 ± 3.44a
13.03 ± 1.70a
45.95 ± 3.30a
114.35 ± 12.14a
100 mg/kg, CAME
23.10 ± 2.20b,f (99.1)
10.20 ± 1.34b (61.1)
42.85 ± 2.66b (42.2)
81.78 ± 15.48b,d,e (61.7)
200 mg/kg, CAME
21.24 ± 1.70b,g (41.5)
11.80 ± 1.30b (26.6)
42.40 ± 3.58b,g (48.3)
82.40 ± 14.00b,c,e (60.5)
400 mg/kg, CAME
22.92 ± 1.90b,h (93.5)
10.40 ± 2.00b (56.8)
42.83 ± 2.48b (42.4)
87.50 ± 11.76b,c,d (50.8)
100 mg/kg, CAAE
22.58 ± 1.56b (83)
9.50 ± 2.05b (76.2)
42.43 ± 2.05b (47.9)
78.35 ± 10.86b,g,h (68.2)
200 mg/kg, CAAE
21.10 ± 2.25b (37.2)
11.10 ± 2.14b (41.7)
42.63 ± 2.00b (45.2)
75.78 ± 7.94b,f,h (73.0)
400 mg/kg, CAAE
21.80 ± 2.20b (58.8)
9.00 ± 1.44b (87.0)
41.48 ± 2.61b (60.8)
74.52 ± 9.20b,f,g (75.4)
400 mg/kg, CAAF
22.80 ± 1.90b,j (89.8)
12.50 ± 1.60b (11.4)
45.30 ± 3.11b (8.8)
77.40 ± 30.39b,j (70.0)
400 mg/kg, CABF
22.28 ± 2.12b (73.7)
10.10 ± 2.70b,i (63.3)
43.30 ± 4.32b,i (36.1)
81.45 ± 21.38b (62.3)
400 mg/kg, CACF
23.03 ± 2.20b,i,j (96.9)
9.38 ± 2.92b,i,j (78.8)
40.05 ± 4.02b,i,j (80.3)
69.50 ± 6.98b,i,j (84.9)
100 mg/kg, silymarin
23.12 ± 1.85 b,c,d,e,f,g,h,i,j,k (99.70)
9.43 ± 1.51 b,c,d,e,f,g,h,i,j,k (77.8)
39.85 ± 4.02 b,c,d,e,f,g,h,i,j,k (82.9)
61.63 ± 8.11 b,c,d,e,f,g,h,i,j,k (99.8)
Compared with anormal control, bnegative control, cCAME100, dCAME200, eCAME400, fCAAE100, gCAAE200, hCAAE400, iCAAF, jCABF, and kCACF. . HDL, high-density lipoprotein; LDL, low-density lipoprotein; TC, total cholesterol; TGs, triglycerides; CAAE, aqueous extract of C. africana; CAME, 80% methanol extract of C. africana; CABF, butanol fraction of C. africana; CAAF, aqueous fraction of C. africana; CACF, chloroform fraction of C. africana, mg/kg, milligram per kilogram; mg/dl, milligram per deciliter.