Research Article

Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats

Table 3

Effects of crude extracts and solvent fractions of the 80% methanol extract of C. africana stem bark on lipid profiles of rats orally administered 2 g/kg APAP (mean ± SEM).

GroupHDL (mg/dL)LDL (mg/dL)TC (mg/dL)TGs (mg/dL)

Normal control23.13 ± 1.658.40 ± 2.0538.60 ± 4.0261.55 ± 14.02
Negative control19.90 ± 3.44a13.03 ± 1.70a45.95 ± 3.30a114.35 ± 12.14a
100 mg/kg, CAME23.10 ± 2.20b,f (99.1)10.20 ± 1.34b (61.1)42.85 ± 2.66b (42.2)81.78 ± 15.48b,d,e (61.7)
200 mg/kg, CAME21.24 ± 1.70b,g (41.5)11.80 ± 1.30b (26.6)42.40 ± 3.58b,g (48.3)82.40 ± 14.00b,c,e (60.5)
400 mg/kg, CAME22.92 ± 1.90b,h (93.5)10.40 ± 2.00b (56.8)42.83 ± 2.48b (42.4)87.50 ± 11.76b,c,d (50.8)
100 mg/kg, CAAE22.58 ± 1.56b (83)9.50 ± 2.05b (76.2)42.43 ± 2.05b (47.9)78.35 ± 10.86b,g,h (68.2)
200 mg/kg, CAAE21.10 ± 2.25b (37.2)11.10 ± 2.14b (41.7)42.63 ± 2.00b (45.2)75.78 ± 7.94b,f,h (73.0)
400 mg/kg, CAAE21.80 ± 2.20b (58.8)9.00 ± 1.44b (87.0)41.48 ± 2.61b (60.8)74.52 ± 9.20b,f,g (75.4)
400 mg/kg, CAAF22.80 ± 1.90b,j (89.8)12.50 ± 1.60b (11.4)45.30 ± 3.11b (8.8)77.40 ± 30.39b,j (70.0)
400 mg/kg, CABF22.28 ± 2.12b (73.7)10.10 ± 2.70b,i (63.3)43.30 ± 4.32b,i (36.1)81.45 ± 21.38b (62.3)
400 mg/kg, CACF23.03 ± 2.20b,i,j (96.9)9.38 ± 2.92b,i,j (78.8)40.05 ± 4.02b,i,j (80.3)69.50 ± 6.98b,i,j (84.9)
100 mg/kg, silymarin23.12 ± 1.85 b,c,d,e,f,g,h,i,j,k (99.70)9.43 ± 1.51 b,c,d,e,f,g,h,i,j,k (77.8)39.85 ± 4.02 b,c,d,e,f,g,h,i,j,k (82.9)61.63 ± 8.11 b,c,d,e,f,g,h,i,j,k (99.8)

Compared with anormal control, bnegative control, cCAME100, dCAME200, eCAME400, fCAAE100, gCAAE200, hCAAE400, iCAAF, jCABF, and kCACF. . HDL, high-density lipoprotein; LDL, low-density lipoprotein; TC, total cholesterol; TGs, triglycerides; CAAE, aqueous extract of C. africana; CAME, 80% methanol extract of C. africana; CABF, butanol fraction of C. africana; CAAF, aqueous fraction of C. africana; CACF, chloroform fraction of C. africana, mg/kg, milligram per kilogram; mg/dl, milligram per deciliter.