Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats

Table 5

Effects of high doses (400 mg/kg) of crude extracts and solvent fractions of methanol extract on SPB-induced sleeping time in rats orally administered 2 g/kg APAP (mean ± SEM).

Group	Sleep duration (minutes)
Normal control, vehicle + SPB	75.70 ± 6.60
Negative control, APAP + SPB	161.33 ± 9.70^a
CAME + SPB	80.25 ± 11.44
CAAE + SPB	75.80 ± 12.00
CAME + APAP + SPB	91.60 ± 4.73^b,d,e,f (81.4)
CAAE + APAP + SPB	129.30 ± 3.06^b (37.4)
CAAF + APAP + SPB	102.80 ± 5.70^b,f,g (68.4)
CABF + APAP + SPB	128.50 ± 7.94^b (38.3)
CACF + APAP + SPB	132.80 ± 5.44^b (33.3)
Silymarin, 100 mg/kg + APAP + SPB	85.25 ± 5.70^b,d,e,f,g (88.8)

Compared with ^anormal control, ^bnegative control, ^cCAME, ^dCAAE, ^eCAAF, ^fCABF, and ^gCACF. Numbers in the bracket show percent protection. APAP: acetaminophen, CAAE: aqueous extract of Cordia africana, CAAF: aqueous fraction of Cordia africana, CABF: butanol fraction of Cordia africana, CACF: chloroform fraction of Cordia africana, CAME: 80% methanol extract of Cordia africana, mg/kg: milligram per kilogram, NS: normal saline, and SPB: sodium pentobarbital.