Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and CEA as the Potential Prognostic Biomarkers for Colorectal Cancer

Table 1

Survival analysis using the Kaplan–Meier and compared by the log-rank test.

Characteristics		N	Mean OS (months)	X^2	value
Age	<65 Y	87	51.5	8.3	0.004
	≥65 Y	243	41.7
Sex	Male	198	41	6.7	0.01
	Female	132	48.6
Primary site	Rectum	129	47.4	2.1	0.144
	Colon	201	42.3
Tumor size	<5 cm	205	44.1	0.1	0.829
	5+ cm	125	45
T stage	T0–T2	68	48.7	2.3	0.138
	T3–T4	262	43.2
N stage	N0	185	48.5	8.9	0.003
	N1–N3	145	38.7
M stage	M0	275	46.9	17.9	<0.001
	M1	55	30.7
Stage	I-II	163	49.2	9.1	0.003
	III-IV	167	39.2
NLR	<3.03 (low)	176	49.7	16.6	<0.001
	≥3.03 (high)	154	37.4
PLR	<149.73 (low)	148	49.2	9.7	0.002
	≥149.73 (high)	182	40.2
CEA (ng/mL)	<13.4 (low)	244	47.9	17.9	<0.001
	≥13.4 (high)	86	33.3
CEA + NLR	Low	141	52.6	24.4	<0.001
	High	189	37.4
CEA + PLR	Low	117	51.6	13.4	<0.001
	High	213	40.4
NLR + PLR	Low	116	52	15.5	<0.001
	High	214	40
CEA + NLR + PLR	Low	94	54.7	19.3	<0.001
	High	236	40.2
BMI	<21.7 (low)	155	35.1	35.5	<0.001
	≥21.7 (high)	175	52.3

NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; CEA, carcinoembryonic antigen; BMI, body mass index.